@InProceedings{BockSáRakTraAnd:2019:LaSuMo,
author = "Bock, Eduardo Guy Perp{\'e}tuo and S{\'a}, Rosa Correa Leoncio
de and Rakebrandt, Jan-Hendric and Trava-Airoldi, Vladimir Jesus
and Andrade, Aron",
affiliation = "{} and {Instituto Nacional de Pesquisas Espaciais (INPE)} and {}
and {Instituto Nacional de Pesquisas Espaciais (INPE)}",
title = "Laser surface modification and characterization of titanium for
endothelialization of ventricular assist devices",
booktitle = "Proceedings...",
year = "2019",
organization = "KNMF User Meeting",
abstract = "Ventricular Assist Devices (VAD) are pumps that stabilize
hemodynamics of patients in end stage of congestive heart failure
until their recovery or cardiac transplantation [1- 3]. Typically,
titanium is the biomaterial chosen for machining processes of VADs
because it provides stable biological integration without
compromising implant biocompatibility. A promising scientific
trend is to develop biofunctional materials that integrate with
the surrounding endothelial cells that line the artery to afford a
prohealing functional response [4, 5]. Biofunctional surfaces for
VADs became possible through coatings and surface modification in
order to improve the interface between biomaterial and assisted
organ [6]. Our previous studies with Plasma Electrolytic Oxidation
(PEO) technique formed a promising textured oxide layer with
scaffolding characteristics and pore size proportional to
endothelial cells of circulating blood [6, 7]. The textured layer
created by PEO is capable of promoting endothelialization in vitro
as shown with in vitro tests performed with Human Umbilical Vein
Endothelial Cells (HUVEC) [7, 8]. The aim of the experiments is to
promote a textured surface similar to that obtained by PEO process
but using laser materials processing available in KNMF. Unlike
micro arcs created in PEO [9, 10], the interaction of laser with
metal surface can be controlled at micro and nano levels [11, 12].
Thus, we expect to alter morphology and topography, creating pores
and scaffolds of size between 5 to 20 \μm increasing
adhesion of endothelial cells and reducing hemolysis inside VADs
[8].",
conference-location = "Karlsruhe, Germany",
conference-year = "19-20 Feb.",
targetfile = "Poster KNMF 2019 (1).pdf",
urlaccessdate = "27 abr. 2024"
}